Clinical Trials of DDW

S.NoAuthorYearsCountryStudy typeTumorNo. Of
patients		DDW Levels
(ppm)		Main result
1Somlyai et al.
(Somlyai et al.,
2021b)		2021HungaryRetrospectiveNSCLC18325–105Compared to MST of historical control
(8–12 months), the combination of DDW and conventional therapies increased the
MST by six- and fivefold (61.9 and
48.4 months)
2Somlyai et al.
(Somlyai et al.,
2023)		2023HungaryRetrospectiveGBM5585, 65, 45, and 25Conventional therapies supplemented
with DDW achieved a longer MST
(30 months) compared to the historical
control (12.1–14.6 months)
3Kovács et al.
(Kovács et al.,
2022)		2022HungaryRetrospectiveMultiple
tumors		204105, 85, 65, 45, and 25DDW consumption prevented tumor
recurrence*
4Kovács et al.
(Kovács et al.,
2011)		2011HungaryProspective and
Retrospective		 PC11385 ppm and 25–105DDW prolonged MST (11.02 years) in
patients with PC.
5Krempels et al.
(Krempels et al.,
2008)		2008HungaryRetrospectiveBM425–95The survival times of four lung cancer
patients with BM who received DDW
combined with conventional treatment
were 26.6, 54.6, 21.9, and 33.4 months,
respectively, which were noticeably longer
than the median survival time (MST =
4–6 months) reported in previous
literature
6Gyöngyi et al.
(Gyöngyi et al.,
2013)		2011HungaryRetrospectiveLC12925–105The combination of DDW and
conventional treatment extends the
survival of LC patients, especially female
patients with tumor overexpression of
cancer-related genes (MST =
74.1 months)
7Krempels et al.
(Krempels et al.,
2013)		2013HungaryRetrospectiveBC23265–105DDW consumption in addition to the
conventional therapies prolonged the
survival of BC patients (MST for earlystage
BC: 217 months; MST for advanced
BC: 52 months). And theMST for patients
who received DDW therapy at least twice
was 293 months, compared to 108 months
for those who received a single DDW
therapy
8Boros et al.
(Boros et al.,
2021)		2021HungaryRetrospectivePC8645, 65, and 85The MST for patients consuming DDW
parallel to the conventional therapies was
19.6 months, in comparison with
6.36 months for patients accept
chemotherapy alone

BC: breast cancer, BM: brain metastases, D: deuterium, DDW: deuterium-depleted water, GBM: glioblastoma multiforme, LC: lung cancer, MST: median survival time, NSCLC: non-small cell lung cancer, No.: number, PA: pancreatic adenocarcinoma, PCa: prostate cancer, PCb: pancreatic carcinoma, *: The MST, was not calculable due to the extremely low death rate (13/204).

Evidence

Somlyai et al.
Naturally occurring deuterium is essential for the normal growth rate of cells.
Pre-clinical and clinical data confirm the anticancer effect of deuterium depletion.
Deuterium has a key role in tumour development – new target in anticancer drug development.
Deuterium depletion inhibits lung cancer cell growth and migration in vitro and results in severalfold increase of median survival time of non-small cell lung cancer patients receiving conventional therapy.
A preliminary study indicating improvement in the median survival time of glioblastoma multiforme patients by the application of deuterium depletion in combination with conventional therapy.
The biological effects of deuterium-depleted water, a possible new tool in cancer therapy.
Naturally occurring deuterium may have a central role in cell signalling.
Biological significance of naturally occurring deuterium: the antitumor effect of deuterium depletion.
Deuterium content of the organic compounds in food has an impact on tumor growth in mice.
Effect of systemic subnormal deuterium level on metabolic syndrome related and other blood parameters in humans: a preliminary study.
Preliminary study on the effect of systemic subnormal deuterium level on metabolic syndrome-related and other blood parameters in humans.

Kovács et al.
Deuterium depletion may delay the progression of prostate cancer.
Blocking the increase of intracellular deuterium concentration prevents the expression of cancer-related genes, tumor development, and tumor recurrence in cancer patients.

Krempels et al.
A retrospective study of survival in breast cancer patients undergoing deuterium depletion in addition to conventional therapies.
A retrospective evaluation of the effects of deuterium depleted water consumption on 4 patients with brain metastases from lung cancer.

Gyöngyi et al.
Deuterium depleted water effects on survival of lung cancer patients and expression of Kras, Bcl2, and myc genes in mouse lung.
Deuterium depletion can decrease the expression of C-myc Ha-ras and p53 gene in carcinogen-treated mice.

Boros et al.
Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle.
Deuterium depletion inhibits cell proliferation, RNA and nuclear membrane turnover to enhance survival in pancreatic cancer.